University of Medicine and Pharmacy of Craiova Doctoral School Phd Thesis Clinical and Morphological Study of Lymphadenopathy of Tuberculous Etiology

Scientific Coordinator: Professor Dr. Iancu Emil PLEȘEA PHD Student: Gigi CĂLIN 2014 CONTENTS OF PHD TABLE OF CONTENTS..................................... 1 ABBREVIATIONS.......................................... VI STAGE OF KNOWLEDGE 1 CHAPTER I TUBERCULOSIS GENERALITIES... 2 INTRODUCTION....................................... 3 ETIOLOGY......................................................... 4 PATOGENY...................................................... 4 Transmission...................................................... 4 Gateway and path.................................................. 5 Virulence............................................................ 5 Consecutive events of penetration bacilli in the body......... 7 Algorithm immune mechanisms in TB........................... 8 Interactions between macrophages and MT..................... 10 Granuloma composition, formation............................. 10 Evaluation of host immune response by MT..................... 25 DISEASE LOCATION................................................. 29 DRUG-RESISTANT TB .................................... 29 EPIDEMIOLOGY............................................. 32 Demographic indicators............................................ 32 Incidence............................................................. 34 Prevalence............................................................ 39 Mortality............................................................ 40 CHAPTER I EXTRAPULMONARY